Simulating CNVs

[adurasiwam3]

Hi everyone,

I would like to use several CNV tools on a common dataset and compare the results.

How should I go about simulating a genome with CNVs in known positions? I know how to simulate reads from a 'normal' genome, but I was wondering if there was a tool out there that will 'insert' CNVs into a normal genome.

Any help/comments will be much appreciated.

Thanks!

[abolia]

Hi adurasiwam3,

I saw your post while searching for simulators. I am in the same boat now and looking for a simulator in which we can insert Translocations into a normal genome and then create raw reads from it. Did you have any luck with it.

Your help or suggestions are appreciated.

Thanks!