GATK can't work with reference genome provided by other web site ,but GATK only have given human reference geonome. So,does GATK only work for human species?
thanks!
thanks!
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It works fine for other species. I use it mostly in mice, though it's certainly easier to do some things in humans due to the existence of the 1000 genomes project. -
Which mice genome you used ? Does it download in UCSC ?Comment
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mm9 from UCSC as well as some of the other strains from the Sanger Institute.Comment
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thank you ! I try it again.Comment
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM
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