I have a large number of annotated indels and I am trying to pick out which ones might be damaging. Frameshifts are easy enough to pick out, but I am curious if any of my non-frameshift indels might affect protein function/folding.
Does anyone have anyone have any recommended methods for doing this? Im guessing I need some sort of protein folding prediction software. Maybe something that provides some sort of qualifying score like how SIFT, PolyPhen2, etc. provide for SNPs.
Commandline is preferred, as is being free, but neither are required.
Thank you very much.
Does anyone have anyone have any recommended methods for doing this? Im guessing I need some sort of protein folding prediction software. Maybe something that provides some sort of qualifying score like how SIFT, PolyPhen2, etc. provide for SNPs.
Commandline is preferred, as is being free, but neither are required.
Thank you very much.