Gene expression signature

[gcsaa]

Hi All,

Just wonder how to derive gene expression signature. In my mind, gene expression signature (GES) could be a specific pattern or a score. What is the link between identifying a subset risky mRNA and GES derivation. Is that GES derivation starts from such a subset? If GES is a pattern, could that be obtained from cluster analysis? If GES is a score, could linear model be helpful?

Thanks,

gcsaa