I have identified frequency of SNPs, heterozygotes and homozygotes per 100kb for my eukaryotic species (which is maintained for 100 generations by inbreeding) by readmapping illumina paired-reads to reference genome. From Drake et al. Genetics, 1998, it is inferred that fixed mutations for eurkayotes (mutation rate are measured in substitutions) is 0.003 mutations per genome per generation. Can I use this for mutation rate calculation for of my eurkaryotic species?. How can I correlate my mutation rate to zygosity?
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...-
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