what's the difference between transcription factor binding profile and transcription factor binding site? thanks for your answering.
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Here's how I'd interpret these phrases:
TF binding site: specific location on the genome where a TF binds. In the canonical scenario, this would be the where the binding motif is located.
TF Binding profile: in a ChIP-seq experiment, the pattern of read pileups scores across a binding site and vicinity. For example, you may take all the promoter regions and average the read coverage at every base form 1000 bp upstream of each TSS through to the TSS; these 1000 points would be a binding profile for that ChIP in promoters.
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