The higher the control size the merrier
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You could decide svd value after the first run, looking at the scree plot.
The higher the control size the merrier
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CoNIFER:CNV detection tool
I am trying to run conifer and not sure about the SVD normalization like how its is done. How the sample amount effects the analysis quality. what does removal of svd components mean. while calling CNV how on what basis do we set the threshold value? How can we measure the sensitivity and the specificity of the result.
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...07-08-2024, 03:19 PM
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