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Can we list all the available ( open source and commercial) parallel (written using MPI / Map Reduce etc) bioinformatics tools. It can include tools that cover both secondary and tertiary analysis i,e from Assembly to Annotation to SNP discover etc. Thank you.
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Here is a read mapper using MapReduce/Hadoop:
Schatz. CloudBurst: highly sensitive read mapping with MapReduce. Bioinformatics (2009) vol. 25 (11) pp. 1363-9 -
Where do I start with this Map Reduce fad and is it as bad as Web 2.0, which is as exciting as my grandmother finding out about the "any key" concept?Originally posted by geschickten View Post
Map Reduce is a simple model that has been implicit in the design and workflow of parallel processes some time. Most short read aligners can be used in a Map Reduce model, and should be included. For example, you split the reads in to N chunks (usually while converting the Illumina/Solid/ect. input files to FASTQ), you run for each chunk in parallel using an instance of the mapping tool (typically implemented in a multithreaded fashion to take advantage of shared memory), and then merge the results (using maq merge or samtools merge etc.). This is clearly obeying the map reduce model. In fact, programs like BFAST actually come with pipeline scripts to operate in such a model using SGE/PBS schedulers.
Specific computer clusters like hadoop have APIs (say in Java) that help with the map reduce model, but is lacking high performance computing since most code is written in C.
My 1.5 cents (recession).Comment
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Yes the MapReduce model in and of itself is nothing new. But the availability of cloud services like AWS EC2 and software like Hadoop have made it that much more accessible to those who aren't C gurus and don't want to deal with the likes of sockets, locks, and other hassles of multithreaded processing. Hadoop can work on much less expensive hardware and can scale a lot more easily (as far as the programmer/end user is concerned). And in the end, if tuned correctly (Hadoop MR is much easier to tune than C code), the ability to scale will outweigh the supposed performance penalty of Java vs. C (which, I might add is a dinosaur of a concept and doesn't hold as true anymore).Comment
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Have you never heard of Hadoop streaming? Of course Hadoop can interact with programs written in other language including C, Perl, etc.Comment
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BTW, the SEQAnswers software wiki has categories for both MapReduce & Hadoop, so a good way to find tools is to browse thereComment
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Data variability is still an issue in sequencing technologies despite the advances in reproducibility and accuracy of these platforms. But the problem does not originate in the sequencing itself, but in the previous steps, before the sample reaches the sequencer.
The first step is collection, followed by preservation and sample preparation for analysis. Most scientists overlook those steps, but not being careful might just be skewing the experiment’s results.
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Introduction
Single-cell sequencing technologies have undergone remarkable advances over the past decade, transitioning from low-throughput experimental approaches to highly scalable platforms capable of...05-22-2026, 06:42 AM
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