From the original paper: "it first identifies all orfs longer than some specified threshold value, and scores each one in all six reading frames. Those that score higher than a designated threshold in the correct reading frame are then selected for further processing".
the further processing is detailed in the first paper & then modified in the second paper, and largely concerns coping with overlapping reading frames.
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GLimmer: How does the module 'glimmer' use the model to find the putative genes
Hi all,
Can someone explain how Glimmer (gene prediction tool) uses the module 'glimmer' to find the putative genes, using the IMM model. How does it identify the orf in the new genome?
The articles explain mainly the selection of the training data used to build the model and the model itself. It is mentioned that the model is used to find putative orfs in the genome but no detailed explanation of the procedure
. Can someone give me the details of the same or relevant articles? Kindly help. Thanks
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Metagenomics has improved the way researchers study microorganisms across diverse environments. Historically, studying microorganisms relied on culturing them in the lab, a method that limits the investigation of many species since most are unculturable1. Metagenomics overcomes these issues by allowing the study of microorganisms regardless of their ability to be cultured or the environments they inhabit. Over time, the field has evolved, especially with the advent...09-23-2024, 06:35 AM -
During the COVID-19 pandemic, scientists observed that while some individuals experienced severe illness when infected with SARS-CoV-2, others were barely affected. These disparities left researchers and clinicians wondering what causes the wide variations in response to viral infections and what role genetics plays.
Jean-Laurent Casanova, M.D., Ph.D., Professor at Rockefeller University, is a leading expert in this crossover between genetics and infectious...09-09-2024, 10:59 AM
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