Seqanswers Leaderboard Ad

Collapse

Announcement

Collapse
No announcement yet.
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Redundancy in TCGA data

    maf file in TCGA have redundancy on most genes (See below a example). Can anyone help me in this issue? This is not only in mutation annotation format files but also in RNA-seq to. I don't know what this mean.
    Why the same gene is replicated by rows???

    Ex:
    A4GNT 51146 broad.mit.edu 37 3 137843364 137843364 + Silent SNP T C C TCGA-CJ-4882-01A-02D-1429-08 TCGA-CJ-4882-11A-01D-1429-08 Somatic Phase_I Capture Illumina GAIIx
    A4GNT 51146 broad.mit.edu 37 3 137843364 137843364 + Silent SNP T C C TCGA-CJ-4882-01A-02D-1429-08 TCGA-CJ-4882-11A-01D-1429-08 Somatic Phase_I Capture Illumina GAIIx
    A4GNT 51146 broad.mit.edu 37 3 137843364 137843364 + Silent SNP T C C TCGA-CJ-4882-01A-02D-1429-08 TCGA-CJ-4882-11A-01D-1429-08 Somatic Phase_I Capture Illumina GAIIx
    A4GNT 51146 broad.mit.edu 37 3 137843364 137843364 + Silent SNP T C C TCGA-CJ-4882-01A-02D-1429-08 TCGA-CJ-4882-11A-01D-1429-08 Somatic Phase_I Capture Illumina GAIIx

    Thanks a lot

  • #2
    There's multiple version of KIRC mafs in various directories.
    I'm not sure which one is gospel and which ones are apocryphal.

    ____ my notes ... _____

    -bash-3.00$ grep -n "A4GNT" *.ma* | grep 137843364 | grep "TCGA.CJ.4882" | cut -f1-3
    An_KIRC_Freeze_1.4_Broad_184_Capture.release.cleaned.maf:10685:A4GNT 51146 broad.mit.edu
    An_KIRC_Freeze_1.4_Broad_184_Capture.release.cleaned.maf.1:10685:A4GNT 51146 broad.mit.edu
    BI_and_BCM_1.4.aggregated.tcga.somatic.maf:21903:A4GNT 51146 broad.mit.edu
    BI_and_BCM_1.4.aggregated.tcga.somatic.maf.1:21903:A4GNT 51146 broad.mit.edu
    BI_and_BCM_1.4.aggregated.tcga.somatic.maf.2:21903:A4GNT 51146 broad.mit.edu
    BI_and_BCM_1.4.aggregated.tcga.somatic.maf.3:21903:A4GNT 51146 broad.mit.edu
    PR_TCGA_KIRC_PAIR_Capture_All_Pairs_QCPASS.aggregated.capture.tcga.uuid.somatic.maf:21924:A4GNT 51146 broad.mit.edu
    -bash-3.00$ ls -l An_KIRC_Freeze_1.4_Broad_184_Capture.release.cleaned.maf
    -rw-rw-r-- 1 finneyr finneyr 2703818 Jan 30 2012 An_KIRC_Freeze_1.4_Broad_184_Capture.release.cleaned.maf
    -bash-3.00$ ls -l BI_and_BCM_1.4.aggregated.tcga.somatic.maf
    -rw-rw-r-- 1 finneyr finneyr 21113158 Aug 8 2012 BI_and_BCM_1.4.aggregated.tcga.somatic.maf
    -bash-3.00$ ls -l BI_and_BCM_1.4.aggregated.tcga.somatic.maf
    -rw-rw-r-- 1 finneyr finneyr 21113158 Aug 8 2012 BI_and_BCM_1.4.aggregated.tcga.somatic.maf
    -bash-3.00$ ls -l PR_TCGA_KIRC_PAIR_Capture_All_Pairs_QCPASS.aggregated.capture.tcga.uuid.somatic.maf
    -rw-rw-r-- 1
    finneyr finneyr 32848977 Dec 6 12:10 PR_TCGA_KIRC_PAIR_Capture_All_Pairs_QCPASS.aggregated.capture.tcga.uuid.somatic.maf
    -bash-3.00$ grep -n "A4GNT" *.ma* | grep 137843364 | grep "TCGA.CJ.4882" | cut -f1 -d":" | awk '{print "ls -l "$1}' | bash
    -rw-rw-r-- 1 finneyr finneyr 2703818 Jan 30 2012 An_KIRC_Freeze_1.4_Broad_184_Capture.release.cleaned.maf
    -rw-rw-r-- 1 finneyr finneyr 3747830 Oct 23 16:24 An_KIRC_Freeze_1.4_Broad_184_Capture.release.cleaned.maf.1
    -rw-rw-r-- 1 finneyr finneyr 21113158 Aug 8 2012 BI_and_BCM_1.4.aggregated.tcga.somatic.maf
    -rw-rw-r-- 1 finneyr finneyr 23056811 Oct 19 16:55 BI_and_BCM_1.4.aggregated.tcga.somatic.maf.1
    -rw-rw-r-- 1 finneyr finneyr 23056811 Nov 5 12:00 BI_and_BCM_1.4.aggregated.tcga.somatic.maf.2
    -rw-rw-r-- 1 finneyr finneyr 23056811 Jan 9 12:48 BI_and_BCM_1.4.aggregated.tcga.somatic.maf.3
    -rw-rw-r-- 1 finneyr finneyr 32848977 Dec 6 12:10 PR_TCGA_KIRC_PAIR_Capture_All_Pairs_QCPASS.aggregated.capture.tcga.uuid.somatic.maf


    Comment

    Latest Articles

    Collapse

    • seqadmin
      Recent Advances in Sequencing Analysis Tools
      by seqadmin


      The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...
      05-06-2024, 07:48 AM
    • seqadmin
      Essential Discoveries and Tools in Epitranscriptomics
      by seqadmin




      The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...
      04-22-2024, 07:01 AM

    ad_right_rmr

    Collapse

    News

    Collapse

    Topics Statistics Last Post
    Started by seqadmin, Yesterday, 06:57 AM
    0 responses
    11 views
    0 likes
    Last Post seqadmin  
    Started by seqadmin, 05-06-2024, 07:17 AM
    0 responses
    16 views
    0 likes
    Last Post seqadmin  
    Started by seqadmin, 05-02-2024, 08:06 AM
    0 responses
    19 views
    0 likes
    Last Post seqadmin  
    Started by seqadmin, 04-30-2024, 12:17 PM
    0 responses
    24 views
    0 likes
    Last Post seqadmin  
    Working...
    X