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  • medalofhonour
    Member
    • Jul 2011
    • 18
    #1

    Longer chromosomes, lesser coverage - makes sense ?

    I am currently trying to find average coverage across each chromosome for my exome capture data.

    When I do so, I always find that longer chromosomes (for example, chromosome 1 always has a lower average coverage as compared to other chromosomes).

    Has anyone else observed this before ? If so, how do you normalize by chromosome length ?
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