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  • jkl
    Junior Member
    • Oct 2011
    • 1

    #1

    snpEff - two SNPs in one codon

    Hi,
    in my list of varinat calls, there are many cases of two SNPs affecting the same codon.
    When using snpEff, the effects of the SNPs on the amino acid sequence, however, are only given for each SNP individually. Any effect of a second SNP is not taken into account for the described codon change.

    Does anyone have proposals how to avoid the these 'false' calls?
    Did I miss any corresponding snpEff option?

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