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  • mhadidi2002
    Member
    • Jun 2011
    • 24
    #1

    BLAST best hit?

    Hello,

    I would like to ask about the standalone BLAST output best hit. Is it the first match for a given query sequence is always the best hit? As long as I know, it is sorted based on the E-value, the best match (with the lowest E-value) comes in the first, followed by the others. Right?

    Best Regards,
    BioinfGuy
    Tags: blast
    • rhinoceros
      Senior Member
      • Apr 2013
      • 372
      #2
      The lowest e-value doesn't necessarily always mean 'the best', but in most cases, yes. Even more so if you mask regions of low complexity..
      savetherhino.org

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