Can any one help with Lander waterman equations?

[D.Alshehri]

if we sequence a 10 mb genome to 10 fold coverage;
a) what is the chance that any given base is not sequenced?
b) if the avrage read length is 400bp, how many reads would you need?
c) if there are no repeats, estimate the number of gaps?
d) what factors can cause gaps in the genome?

thanks indeed for any help.

[mastal]

Can any one help with Lander waterman equations?

see http://en.wikipedia.org/wiki/DNA_sequencing_theory

[D.Alshehri]

thanks alot