question on filtering variants

[kjaja]

Hi,

I am working on identifying variants in affected individuals the we exome sequenced. Going through the variants after filtering out variants in the 1000 Genomes project, dbSNP and ESP6500, I was wondering if there is a list out there for variants in genes that we need to not consider for follow up as they always appear in every sequencing project such as the MUC genes. Is there such a list or a list of hypervariable genes publically available that can be used to remove variants in genes reported in these lists?

thanks

[Knaus]

You could visit www.gene-talk.de, set up a free account and upload your data.
Afterwards you can filter for rare variants, your are likely to filter out common variants. use the blacklist filter (annotation filter) to ged rid of common sequencing artifacts.

In our database you will find annotations from hundreds of users reporting highly variable genes and polymorphic variants. you can filter them out...

.. you are welcome to test all filtertools and the whole platform....

if you find candidate variants, provide annotations that would help the community or ask an expert about its medical implications...