Hello all,
I have some novel mouse lncRNAs.
In order to infer its function in the context of human diseases, I want to find human genes orthologous to them.
Since it is noncoding and less conserved, I cannot just use a sequence similarity-based tool such as InParanoid or orthoMCL.
But then, all synteny detection tools basically return synteny blocks, not doing gene by gene orthology inference.
What I want is that for each of my novel mouse lncRNAs, I want to find human orthologs by both synteny and sequence similarity.
Do you know of any tool that does this?
Please let me know.
Thanks in advance,
HJ.
I have some novel mouse lncRNAs.
In order to infer its function in the context of human diseases, I want to find human genes orthologous to them.
Since it is noncoding and less conserved, I cannot just use a sequence similarity-based tool such as InParanoid or orthoMCL.
But then, all synteny detection tools basically return synteny blocks, not doing gene by gene orthology inference.
What I want is that for each of my novel mouse lncRNAs, I want to find human orthologs by both synteny and sequence similarity.
Do you know of any tool that does this?
Please let me know.
Thanks in advance,
HJ.