Hi i am new. I just noticed that some papers define the region within 1 kb to TSS as "near TSS: while the region over 1kb as "far away from TSS". what 's the speciality of the "1kb" ? especially when one protein owns regions "near TSS" and "far awya from TSS" are there any expected difference?
-
-
The 1Kb distance is pretty arbitrary, in fact you'll find a range of distances in different papers (I've seen up to 5kb upstream to maybe 2kb downstream). There are typically some proteins that bind closer to the actual TSS than others, but the exact distances used to discriminate between things isn't really set in stone.
-
NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification, detection...Today, 06:46 AM -
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM
Comment