SNP Allele-Frequency Determination in Pooled DNA Samples using solexa
When sequencing pooled population DNA Samples, how the relative amounts of each allele in a sample change?
After mapping the short reads, we caculate the SNP frequency(minor,major), can we use this frequency to estimate the frequency in the original sample?
After mapping the short reads, we caculate the SNP frequency(minor,major), can we use this frequency to estimate the frequency in the original sample?
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