are these motifs same ?

[a_mt]

Hi all,

I was doing motif analysis in two phenotypes of the same species and found two motifs. In phenotype-A, poly-A regions was over-represented whereas in phenotype-B, ploy-T region was over-represented (image attached). I am using rGADEM bioconductor package for analysis.

The question I am facing is, are these motifs same ? I think they are same but I am not sure. Is this because of strand bias or something?

Any suggestion would be helpful.

Thank you.

[maubp]

If you don't care about the strand, then yes they are the same (one is the reverse complement of the other).

You're not looking at mRNA are you? If so the poly-A tail is not interesting.

[GenoMax]

If these patterns were identified in two independent phenotypes then they may be different unless you have a reason to believe that they are on opposite strands (as Peter pointed out above)