Does FDR assume that all p-values were adequately powered. IE suppose the the hypothesis are that for a coin flip that that p=q=.5, and all the trials had 100 flips vs. a situation where the number of flips in a trial were subject to a mixing distribution, and a large proportion were <= 4 flips, would FDR perform as well in either case? I suspect that the testing procedure could stand to have a smaller m when calculating p(X(i))<alpha*i/m where X is ordered according to ascending p-values.
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...