It seems to me people always think coverage is the more the better. But if such coverage is gained by increasing the read length but with lower quality, can such coverage gain really be converted into better variant calling?
For example, when you go from HiSeq 2500 rapid mode 2x100 to 2x150, you gained 50% coverage but do you actually have more accurate variant calling?
For example, when you go from HiSeq 2500 rapid mode 2x100 to 2x150, you gained 50% coverage but do you actually have more accurate variant calling?
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