Hi,

It might be a naive question but anyways. I'm using edgeR to analyse RNA-seq data. The idea is just to compare two conditions with no replications. I know that the common dispersion will be set to zero in this case, so I tried to use quantile adjusting as poisson and get exactly the same p-values as using common dispersion with zero.

So my question is: if the common dispersion is set to 0 how are the p-values calculated? are they calculate exactly the same as if I do a quantile adjusting as poisson?

Cheers,

Sergio

It might be a naive question but anyways. I'm using edgeR to analyse RNA-seq data. The idea is just to compare two conditions with no replications. I know that the common dispersion will be set to zero in this case, so I tried to use quantile adjusting as poisson and get exactly the same p-values as using common dispersion with zero.

So my question is: if the common dispersion is set to 0 how are the p-values calculated? are they calculate exactly the same as if I do a quantile adjusting as poisson?

Cheers,

Sergio

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