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Sure, you can still pick up chromosomal and other structural rearrangements with exome sequencing, just not 100% of the time. You're correct that the reason this worked was due to the genes rearranging and effectively merging in the genome. Because of that, the capture kit still got reads that mapped to the end of one or the other of the genes (with the remainder mappable to the other gene).
This would be in contrast to detecting fusion transcripts arising from neighboring genes being coexpressed and spliced together. Those sorts of situations wouldn't be detectable with exome sequencing.
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The answer is that it depends on:
- where fusion junction point lies (it is "well" inside an exon which should be 'captured' properly and both genes involved in fusion should captured properly),
- coverage of sequencing
Whole genome sequencing and RNA-seq are ones of the most used for finding fusion genes and/or translocations.
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For anyone interested: They used dRanger (not publicly available) and Breakpointer in order to detect the fusion from exome data.
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