when using coverageBed within BedTools to identify annotated genes within reference genome (gff file) that are not covered by reads- I understand that a value of 1 indicates that that gene is fully covered by the reads however- a value of less than 1 (does it indicates low coverage?)- and what about (0), does this indicate that the region is not covered at all or there is a possiblity that it is missing from the sequenced chromosome and that's why it showed ) coverage in the reads?- how could we prove that?
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...
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