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  • choijae3
    Junior Member
    • Jan 2014
    • 8

    #1

    bwa-mem -M parameter and SV detection software compatability

    I wanted to ask people with experience using bwa mem to align their reads and use the bam file to detect SVs using programs such as pindel, breakdancer, CNVnator, svdetect.

    I know that the -M parameter is pretty much needed for downstream picard compatibilty for marking duplicates however wouldn't the -M parameter eliminate reads that the SV detecting programs use?

    Anyways I was wondering what people have experience when using bwa-mem for SV detecting.
    Thanks

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