Gene expression and lipids, time-series analysis

[sindrle]

Hi!
I have two data sets; genes and lipids (RNAseq and lipidomics).
I have 6 time points (equal for both data sets).

How can I see how these two data sets influence each other? Should I use i.e. "MixOmics" - approaches, or are there some time-series correlation methods I could use?

Or simply, how do I know if the time-serie of gene X correlate with the time-serie of lipid Y?

Thank you!

[aby]

What organism are you using ? What pathway ?

[sindrle]

Human. Insulin pathway and lipid metabolism are of great interest!

[sindrle]

For simplicity, say you measured 5 gener using RT-PCR, and you measured 8 lipid species. All within the same tissue and at the same 6 time points. And you have 26 observations in each time point for each gene and lipid.

How can you decide the correlation between these series?

Thank you!

[aby]

You might want to use R time series ARIMAX modeling to see time series relation between two series and then model.

[sindrle]

Ok, thank you, Ill try that.