I am entirely new to using sequence and alignment files. Is there a way to convert .BAM to FASTA or FASTQ?
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Not sure if this is the easiest way, but I use BBTools's reformat.sh along with samtools for that.
reformat.sh in=reads.bam out=reads.fq
That requires samtools to be in your path. -
There's also SamToFastq from Picard tools (contrary to its name, it supports BAM files too).Comment
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM -
Proteomics platforms are evolving rapidly, with advances in mass spectrometry and affinity-based approaches expanding what researchers can detect and at what scale. As the field moves toward deeper proteome coverage and clinical applications, scientists face an increasingly complex landscape of tools. This article will explore how researchers are navigating these choices to find the right platform for their work.
The systematic characterization of the human proteome has...07-20-2026, 11:48 AM
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