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  • bio_informatics
    Senior Member
    • Nov 2013
    • 182

    getting gene coordinates

    Hi Members,
    I have bunch of 350+ gene names. These are cancer causing gene to which drugs are approved.
    I want there chromosome name, start, end information.
    How do I get that?

    Kindly advise.
    Last edited by bio_informatics; 09-20-2014, 07:38 AM.
    Bioinformaticscally calm
  • bruce01
    Senior Member
    • Mar 2011
    • 160

    #2
    Biomart is a good place to do this sort of thing.

    From the drop-downs, select "Ensembl Genes <X>", "Homo Sapiens <Y>".

    Filters > Gene > ID list, copy/paste you're 350+ genes into the box.

    Attributes > Gene, select your attributes of interest.

    Good luck!

    Comment

    • bio_informatics
      Senior Member
      • Nov 2013
      • 182

      #3
      Thank you for prompt reply.

      I followed this, but getting a blank file [ only headers ].
      Also, the HTML preview/output consists of headers.




      Originally posted by bruce01 View Post
      Biomart is a good place to do this sort of thing.

      From the drop-downs, select "Ensembl Genes <X>", "Homo Sapiens <Y>".

      Filters > Gene > ID list, copy/paste you're 350+ genes into the box.

      Attributes > Gene, select your attributes of interest.

      Good luck!
      Bioinformaticscally calm

      Comment

      • GenoMax
        Senior Member
        • Feb 2008
        • 7142

        #4
        Your gene ID's have to match the filter selection (kind of Gene ID's) you are making in BioMart. What kind of ID's do you have?

        Comment

        • GenoMax
          Senior Member
          • Feb 2008
          • 7142

          #5
          You can probably find the information at pharmGKB (https://www.pharmgkb.org/downloads/) as well.

          Comment

          • bio_informatics
            Senior Member
            • Nov 2013
            • 182

            #6
            I have gene name(s)- CARD11, ABL2, DICER1
            I was using these in GENE ID list.

            Originally posted by GenoMax View Post
            Your gene ID's have to match the filter selection (kind of Gene ID's) you are making in BioMart. What kind of ID's do you have?
            Bioinformaticscally calm

            Comment

            • bio_informatics
              Senior Member
              • Nov 2013
              • 182

              #7
              This helps a lot.

              This is as per version GrCh 37.

              However, if I want as per 38. Are below filters(steps) correct (?) :-
              UCSC table:
              clade-->mammal, genome-->Human; Assembly--> Dec 2013 GrCh38; Group gene and gene predictions; track --> Refseq Genes; Table --> ref genes

              This has column --> name2


              Originally posted by GenoMax View Post
              You can probably find the information at pharmGKB (https://www.pharmgkb.org/downloads/) as well.
              Last edited by bio_informatics; 09-20-2014, 06:37 PM.
              Bioinformaticscally calm

              Comment

              • GenoMax
                Senior Member
                • Feb 2008
                • 7142

                #8
                That looks right.

                For BioMart search: You should select "Filters" --> "ID_Limit_list" --> "HGNC symbol" in the drop-down.

                Comment

                • bio_informatics
                  Senior Member
                  • Nov 2013
                  • 182

                  #9
                  Thank you for confirming.
                  HGNC Symbol path also worked.
                  Bioinformaticscally calm

                  Comment

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