If I have the substitution scores for the three groups D, E, and K as found in the matrix of the uploaded attachment, how do I find the average substitution score? The book I am reading from says the average substitution score is 2.66, but it is unclear to me how this was derived. Any help would be appreciated.
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NGS has revolutionized clinical microbiology by offering new ways to identify and surveil pathogens without prior knowledge of the target. One popular approach is 16S rRNA and ITS amplicon sequencing, which targets specific microbial markers. But studies are increasingly incorporating shotgun metagenomics, a technique that sequences all DNA from a sample without targeting specific microbial markers. This approach allows more detailed taxonomic classification,...10-30-2026, 06:46 AM
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