calculating mutation burden per TCGA sample

[adrian]

Hi:

in TCGA breast data, I found using expression of genes of interest in the lab, ~120 samples segregate into two groups that have high and low expression of my gene.

I want to summarize that group 1 has higher mutation rate compared to 2nd group. Also I want to summarize the copy number alteration for both groups.

How can I get the summarized value for each groups (perhaps a mean value).

Can I use "mutation count" and 'CNA' columns from Cbioportal clinical sheets.

or Do I have to calculate that per KB of the genome how many mutations are observed?

Appreciate your help.

Thanks
Adrian