I wanted to know what is the best wat to import the reference chromosome into CLC to analyze sequence capture experiment. The sequence capture probes were built based on build 36 human genome. I have the fasta file of the desired chromosome, but then it is without annotation. I also have a gff file of the locations of the probes on the chromosome, and of course I have the 454 sequencing result files. I want to receive as much information as possible, in what genes the mutation, exons, SNPs etc. What should I use as a reference to include all those annotations?
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...
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