I wanted to know what is the best wat to import the reference chromosome into CLC to analyze sequence capture experiment. The sequence capture probes were built based on build 36 human genome. I have the fasta file of the desired chromosome, but then it is without annotation. I also have a gff file of the locations of the probes on the chromosome, and of course I have the 454 sequencing result files. I want to receive as much information as possible, in what genes the mutation, exons, SNPs etc. What should I use as a reference to include all those annotations?
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The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
This convergence of genetics, immunology, and computation...09-01-2026, 05:41 AM
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