help: mutations affecting pathway
Hi all,
I have the somatic mutations of 2 group of patients: responder and non-responder. I would like to show that the non-responder group is due to the damage of a specific pathway (e.g. WNT).
A simple way is to count how many patients in each group has WNT pathway gene mutations and perform a fisher test. If the proportion of patients in the non-responder group is significantly higher than the responder group, it makes sense.
However, I am looking for a more convincing method. Any input is appreciated!
I have the somatic mutations of 2 group of patients: responder and non-responder. I would like to show that the non-responder group is due to the damage of a specific pathway (e.g. WNT).
A simple way is to count how many patients in each group has WNT pathway gene mutations and perform a fisher test. If the proportion of patients in the non-responder group is significantly higher than the responder group, it makes sense.
However, I am looking for a more convincing method. Any input is appreciated!