I have merged VCF files of every individuals of a particular population using VCF merge. But I am not sure which SNP is coming from which individual. I tried to convert the merged VCF file in PGDSpider to generate GENEPOP format data to use in Lositan for Outlier detection. However, Lositan only detects one population. What could be the best way to merge different VCF files for different populations into one Genepop file to use in Lositan for Outlier detection?
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM