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  • DESeq2 and genes related to survival

    I have a dataset with miRNA counts from cancer patients and their survival times and outcomes.

    Is it correct use DESeq2 (or any other similar tool) to find miRNAs that affect survival?

    I figured I could use a survival object in the design formula.

    Code:
    design=~Surv(survival_time, outcome)
    The resulting DE miRNAs are seem to affect survival outcomes. However, I'm not sure if this method makes sense. If it doesn't, feel free to suggest a better approach. Thanks!

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