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  • geertvandeweyer
    Member
    • Jan 2011
    • 14

    #1

    PySAM VCF : add new filter

    Hi,

    I'm trying to add a new filter to a VCF file after processing using pysam. I can add new format fields to the output header using :

    Code:
    vcf_file = pysam.VariantFile(vcf_path)
    new_header = vcf_file.header
    new_header.formats.add('New_Field', 1,"Float", "New_Field_Descr")
    
    vcf_out = pysam.VariantFile(out_path,'w',header=new_header)
    I tried similar apporaches to add filters, but so far haven't succeeded.

    Similary to set a filter field for a VariantRecord, I haven't found the correct syntax.

    Does anybody have working examples on how to do this?


    Edit : I managed to add a new filter definition using :

    Code:
    new_header.add_line('##FILTER=<ID=new_filter,Description="new_filter explained">')
    Now I'm hitting what looks like 'readonly' features of variantrecord.filters

    Code:
    AttributeError: attribute 'filter' of 'pysam.cbcf.VariantRecord' objects is not writable
    Last edited by geertvandeweyer; 04-18-2016, 06:14 AM.

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