Partial Least Square and Single Cells
Dear all,
I'm working with single cell rna sequencing data, I've used already known programs to perform differential expression (such as DeSeq2, SCDE etc)
I recently started to use the 'mixOmics' package under R which allows to do Partial Least Square Analysis therefore taking into account multiple conditions at the same time.
I usually obtain nice scores (beta coeff) for genes that predict conditions yet I was wondering if the PLS approach can be used for single cell data ?
Do any of you have done this already ?
What do you think of this approach,
I'm eager to hear your advice !
Cheers
Claire
I'm working with single cell rna sequencing data, I've used already known programs to perform differential expression (such as DeSeq2, SCDE etc)
I recently started to use the 'mixOmics' package under R which allows to do Partial Least Square Analysis therefore taking into account multiple conditions at the same time.
I usually obtain nice scores (beta coeff) for genes that predict conditions yet I was wondering if the PLS approach can be used for single cell data ?
Do any of you have done this already ?
What do you think of this approach,
I'm eager to hear your advice !
Cheers
Claire