Understanding TMB
I am hoping to further understand how Tumour Mutational Burden is calculated. I understand that it is the overall number of mutations which are present in the overall exome, but is it treated as a flat rate?
i.e. it treats all mutations indel/SNP/CNV equally or how does it weight each mutation? Does it still acknowledge silent mutations?
Does it have to be compared against a 'normal' or just references from databases?
i.e. it treats all mutations indel/SNP/CNV equally or how does it weight each mutation? Does it still acknowledge silent mutations?
Does it have to be compared against a 'normal' or just references from databases?
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