Good RNA folding tools
Does anybody knows a good tool for predicting RNA secondary structure of 160,074 RNA sequences (most about 300 bps long), other than Vienna RNAfold? Even better if the tools is available in a web-server that can support batch queries.
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RNAstructure is another alternative:
CentroidFold is another:
If you have that many sequences, you're better off downloading the command-line versions and running the jobs on a cluster. -
Single sequence structure prediction is extremely unreliable (https://bmcbioinformatics.biomedcent...471-2105-5-140). You're better of building alignments and folding those with e.g. RNAalifold. R-scape will tell you if you there is significant covariation.
I hear CONTRAfold is reasonably accurate, if you must fold single sequences.Comment
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