Hi Everyone,
The CADD data set from Washington U., lists annotation for all potential variants in the human genome, including annotation about amino acid changes. The single letter amino acid code is used. In numerous cases the code 'U' is used for the original, ie reference, amino acid. This is clearly not in the IUPAC single-letter amino acid table.
Can anyone tell me what this refers to, and why? This seems like an error, but maybe there was a reason for it. Either way, its not an IUPAC code, so really shouldn't be used.
Has anyone else had problems with this?
Joe White
Wuxi NextCODE Genomics
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The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
This convergence of genetics, immunology, and computation...09-01-2026, 05:41 AM