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  • aDNA
    Junior Member
    • Apr 2020
    • 1
    #1

    MapDamage strange damage pattern

    Hello,

    I am running MapDamage on some aDNA samples against hg38, and it is showing me damage only on the 3' G-to-A, but not the 5' C-to-T. Does anyone have any idea why this might be happening?

    It is a double stranded library preparation protocol, and represents sequences from a MiSeq (PE) and a HiSeq (SE) run that are merged together post-processing. I also tried running the lanes separately, and MapDamage gave me the same pattern.

    Any input would be greatly appreciated!
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    Tags: ancient dna, bioinformatics, damage patterns, mapdamage
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