False Discovery Rate issue

[slny]

I'm looking for differential expressed genes with mRNA Seq. Currently I'm using edgeR or DEseq for data normalization and differential analysis. However, I'm not sure whether I need to calculate False Discovery Rate (FDR) or not.

Should I calculate FDR in the differential analysis of mRNA Seq data? If so, how to do it?

Thanks a lot!

[A Oshlack]

I believe the topTags() function in edgeR does FDR with Benjamini & Hochberg