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  • Setting up a 454 Bioinformatics center

    We are expanding our Bioinformatics Core to handle 454 data analysis from two dedicated Titanium sequencers. Our users have several applications in mind: lots of metagenomics, some de novo sequencing, some resequencing, some transcription analysis. And I need to plan for having both sequencers running at capacity.

    Two questions:
    1) which are the best Cores that are already doing this sort of thing, and whom do I contact at them for sage advice?
    2) any idea how much horsepower and storage I need? (I realize it's impossible to answer that, but any rules of thumb or words of wisdom would help).
    3) who has the best integrated software for the relatively naiive user? (for example, RDP at MSU has a decent pipeline in development)

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  • seqadmin
    Recent Advances in Sequencing Analysis Tools
    by seqadmin


    The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...
    Today, 07:48 AM
  • seqadmin
    Essential Discoveries and Tools in Epitranscriptomics
    by seqadmin




    The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...
    04-22-2024, 07:01 AM

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