Experimental design based on coverage needed

[bioseq]

I would like to do RNAseq and DNAseq on human samples and need 500x (RNAseq) and 30x (DNAseq) coverage. How do I determine if I can multiplex and then also choose between single-end and paired-end to get this coverage?

Do I simply calculate #reads required from the following?
coverage = (read count x read length)/genome size
30 = (read count x 36)/3GB
read count = 90GB/36
read count = 2.5GB ??!!

Thanks in advance

[HESmith]

Correct. Obviously, longer reads would help :-).