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  • bnfoguy
    started a topic Accessing .vcf.gz files on a Windows platform

    Accessing .vcf.gz files on a Windows platform

    Hello,

    I'm a first timer to bioinformatics research and have recently been working on a project involving genetic variations. I am supposed to use the latest 1k genomes release file which is "ALL.2of4intersection.2010084.genotypes.vcf.gz". I have downloaded the file which is about 61.2GB () but am facing trouble in extracting its contents. I would really appreciate some guidance in this matter.

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  • SEQadmin2
    Beyond CRISPR/Cas9: Understand, Choose, and Use the Right Genome Editing Tool
    by SEQadmin2



    CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).

    Despite this, “CRISPR helped turn genome editing from a specialized technique into
    ...
    07-31-2026, 11:01 AM

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