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  • Mark
    replied
    I like Perl for scripting. It's powerful, very widely used, and has lots of online resources. I also think it's easy to learn to a level that will quickly make you productive. Many people seem to think Python is easy to learn, but the O'Reilly (a publisher of typically great computer books) book "Learning Python" is ~3 times longer than "Learning Perl" and doesn't even cover regular expressions. That's like a driving class that doesn't cover steering. I would steer away from this book if you choose Python. And of course a strong command of unix/linux is highly recommended though I would choose Perl or Python over extensive shell scripting.

    Leave a comment:


  • rnaseek
    replied
    I am biased and I would strongly encourage to start learning Python first and R as well. Lot of people find it easy to learn Python. Getting the hang of awesome unix commands would also be very useful.

    Here are a few links to get started with R and Python

    Leave a comment:


  • Heisman
    replied
    I started teaching myself a year and a half ago (I'm a tech) and still consider myself a novice, so listen to others as well, but I have found that learning linux really well has been very beneficial. Getting a good understanding of how to write bash scripts as well as the basic linux commands (sed/tr/cut/sort/cat/paste/grep) in addition to learning a bit of awk has been tremendously useful for me.

    Leave a comment:


  • Developing programming experience for bioinformatics

    I have an extensive molecular biology background but am relatively new to bioinformatics. Would like to extend my computational/programming skills to maximize utility in analyzing sequencing and other high-throughput data, as well as to improve my own marketability.

    Many job postings refer to some combination of Perl/Python/C++/Java experience. Any suggestions regarding where to focus effort, particularly in a forward-looking manner?

    Thanks for any suggestions.

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  • SEQadmin2
    How Immunogenomics Decodes Immunity’s Genetic Blueprint
    by SEQadmin2




    The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.

    This convergence of genetics, immunology, and computation...
    Today, 05:41 AM
  • SEQadmin2
    Beyond CRISPR/Cas9: Understand, Choose, and Use the Right Genome Editing Tool
    by SEQadmin2



    CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).

    Despite this, “CRISPR helped turn genome editing from a specialized technique into
    ...
    07-31-2026, 11:01 AM

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