Bionanomatrix

[selim27]

Does anyone know about Bionanomatrix sequencing? I need specs. Like throughput, cost, apparatus, etc.

I know that it uses a nanofluidic device to stretch out long linear strands of DNA in nanochannels, and then that DNA molecule is queried with 5 base sequences. These 5 base segments hybridize to the template, revealing sequence information, as well as location information. Every possible 5 base combination is added until the sequence is read.

I need more information though. I am writing a report on this for one of my classes, and the professor wants more specs. I couldn't find anything else when I researched this topic. I was wondering if anyone on this forum can provide more details. This technology is very new, and still under development, so maybe that's why it's hard to come across further details, but I need to learn more.

[Zigster]

is that how it works? I think they might need to pay Pavel Pevzner some royalties b/c that sounds eerily like the sequencing-via-microarray approach that was tried in the '90s

Bionanomatrix seems fairly secretive - i've never gotten responses from my email to them regarding our R users group and I fear their reliance on .Net will mean a lot of closed-source code. In the end the product is sequence not software, so if they can produce reads longer than Sanger that will be pretty spectacular. All will be forgiven.