Ultimately it is arbitrary. I think the E.coli genome project used a 0 near the replication origin, but that need not be followed.
Another possible landmark would be a well known restriction site, perhaps chosen from some previous work on the organism such as a physical map.
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how to determine the fist position of a genome
most of bacteria genome are circle, but in database most are saved in line. I mean they have first position and last position. I used to believe the ori position, which is replication start point, was defined as first position, now i find i am wrong. how is this defined. any help will appreciated.
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The complexity of cancer is clearly demonstrated in the diverse ecosystem of the tumor microenvironment (TME). The TME is made up of numerous cell types and its development begins with the changes that happen during oncogenesis. “Genomic mutations, copy number changes, epigenetic alterations, and alternative gene expression occur to varying degrees within the affected tumor cells,” explained Andrea O’Hara, Ph.D., Strategic Technical Specialist at Azenta. “As...07-08-2024, 03:19 PM
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