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  • Greetings Earthlings

    Greetings everyone-

    I've been lurking here for ~18 months but missed that I was supposed to introduce myself.

    I'm an all-hats computational biologist and "all-purpose geek" as a friend insists on calling me. I've worked on molecular mechanics, protein structure prediction, sequence pattern discovery in academia, and then worked in industry for 8 years on structure-based target discovery, large-scale data integration (primarily http://unison-db.org/), and managing a large research computing environment. I'm now part of a fantastic team in San Francisco working to build sequencing-based diagnostic services.

    Thanks to ECO for creating this forum and to the community for the tools and answers.

    -Reece Hart

Latest Articles

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  • seqadmin
    Addressing Off-Target Effects in CRISPR Technologies
    by seqadmin






    The first FDA-approved CRISPR-based therapy marked the transition of therapeutic gene editing from a dream to reality1. CRISPR technologies have streamlined gene editing, and CRISPR screens have become an important approach for identifying genes involved in disease processes2. This technique introduces targeted mutations across numerous genes, enabling large-scale identification of gene functions, interactions, and pathways3. Identifying the full range...
    08-27-2024, 04:44 AM
  • seqadmin
    Selecting and Optimizing mRNA Library Preparations
    by seqadmin



    Sequencing mRNA provides a snapshot of cellular activity, allowing researchers to study the dynamics of cellular processes, compare gene expression across different tissue types, and gain insights into the mechanisms of complex diseases. “mRNA’s central role in the dogma of molecular biology makes it a logical and relevant focus for transcriptomic studies,” stated Sebastian Aguilar Pierlé, Ph.D., Application Development Lead at Inorevia. “One of the major hurdles for...
    08-07-2024, 12:11 PM

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