We just wanted to say hi to the group as AllSeq has started posting to SEQanswers as an approved vendor. (Personally, I’ve been a part of SEQanswers since 2008 posting as scbaker). We follow all of the platforms and keep a close eye on the NGS market, so feel free to pick our brains if you’d like a neutral opinion on something you’ve read about. We’ve posted something over in the vendor forum if you’re interested in learning more about what we do.
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CRISPR/Cas9 sparked the gene editing revolution for both research and therapeutics.1 But this system still showed severe issues that limited its applications. The most prominent were the heavy reliance on PAM sequences, delivery limitations, double-stranded breaks that prompt unintended edits and cell death, and editing inefficiency (both in targeting and in knock-in reliability).
Despite this, “CRISPR helped turn genome editing from a specialized technique into...07-31-2026, 11:01 AM