the strength of the TF binding

[noha osman]

Hi all,

I have set of transcription factors and their targets , I need to measure the strength of the TF binding

Iam asking, I have to calculate position weight matrix (PWMS) to measure the strength

is there another way to do that

Thanks

[SNPsaurus]

Strength is a vague word and probably not applicable to sequence-based data. A PWM is a reasonable and traditional way to display some aspects of nucleotide preference, barring combinatorial non-linearity.